MCHC (Mean Corpuscular Hemoglobin Concentration)
MCHC is the concentration of haemoglobin within each red blood cell. Unlike MCH (mass), MCHC adjusts for cell size. Persistently high MCHC suggests hereditary spherocytosis or autoimmune haemolysis; low MCHC suggests iron deficiency or thalassaemia.
Normal Range
32–36 g/dL
Reference ranges may vary slightly between laboratories. Always interpret your result in context with your doctor.
Why is MCHC measured?
MCHC is calculated automatically on every CBC. It refines the classification of anaemia, particularly distinguishing hereditary spherocytosis from other causes.
High MCHC means…
High MCHC (above 36 g/dL) is unusual. Causes include hereditary spherocytosis, autoimmune haemolytic anaemia, severe burns, or laboratory artefact.
Low MCHC means…
Low MCHC (below 32 g/dL) accompanies hypochromic anaemias — iron deficiency and thalassaemia.
Symptoms associated with abnormal MCHC
When MCHC is high:
- Symptoms of haemolysis (jaundice, dark urine) if applicable
When MCHC is low:
- Symptoms of underlying microcytic anaemia
How to improve your MCHC
- Persistent high MCHC warrants investigation for haemolytic anaemia.
Frequently asked questions about MCHC
What does high MCHC indicate?
Persistently high MCHC suggests hereditary spherocytosis or autoimmune haemolysis. A blood film and Coombs test are usually next investigations.
Medical Sources
This page is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider about your individual results.